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KMID : 1140120090140010001
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Cancer Prevention Research
2009 Volume.14 No. 1 p.1 ~ p.6
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3-Dimensional Cell Culture System: A Potential Model for Monitoring Effects of Radiotherapy
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Seo Young-Rok
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Abstract
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Recently, one in four Koreans dies of cancer. Cancer is one of the most serious diseases faced not only by Koreans but also by the whole world. Elucidation of molecular and cellular mechanism of cancer is required for minimization of carcinogenesis and maximization of remedial values. In tumor, multiple factors exist simultaneously, which together may significantly influence on radiation-induced apoptosis. Therefore, in order to develop new model it would be needed to consider the effects of combined factors to assess tumor response more realistically. Hypoxia has been known to be a limiting factor in tumor therapy for a long time, but effective solutions haven’t been yet developed though a huge attention has been given to this problem. In addition, other barriers including glucose depletion and acidosis have been raised; it may be needed to be solved to maximize curative values. Nowadays, 3-dimensional (3D) cell culture system has an invaluable role in tumor biology providing the significant insight into radiotherapy. They provide a well defined environment for experimental design similar to an in vivo model. Here, we discussed on the potentiality of 3-dimensional cell culture system in a field of cancer research including radiotherapy.
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KEYWORD
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3-dimensional cell culture system, Cancer, Radiotherapy
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